Macaulay's family once left him home alone, and on Christmas of all times. The children's holiday! Of course he was never completely by himself, he still had those voices whispering inside his head (not to mention Joe Pesci creeping up his doorstep.)
Needless to say, he would never quite be the same again.
So when you find yourself in times of trouble, lonely and forgotten. Remember young Culkin's trials and tribulations. As a famous singer once sang: You are not alone!